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HU-210 is a synthetic cannabinoid that was first synthesized in 1988 from (1R,5S)-myrtenol

by a group led by Raphael Mechoulam at the Hebrew University. HU-210 is 100 to 800 times more potent than natural THC from cannabis and has an extended duration of action.

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HU-210 is a synthetic agonist analog of Δ9-THC, which is the primary psychoactive component of marijuana. HU-210 is a potent central cannabinoid (CB1)

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HU-210 has a binding affinity of 0.061nM at CB1 and 0.52nM at CB2 in cloned human cannabinoid receptors.

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Compared to Delta-9-THC of 40.7nM at CB1. HU-210 is the (–)-1,1-dimethylheptyl analog of 11-hydroxy- Δ8- tetrahydrocannabinol; in some references it is called 1,1-dimethylheptyl- 11-hydroxytetrahydrocannabinol. The abbreviation "HU" stands for Hebrew University.

HU-210, the (–) enantiomer of 11-OH-D8-THC-DMH, has almost all of the cannabinoid activity, while the (+) enantiomer, known as HU-211, is inactive as a cannabinoid and instead acts as an NMDA antagonist having neuroprotective effects.

HU-210 promotes proliferation, but not differentiation, of cultured embryonic hippocampal neural stem and progenitor cells likely via a sequential activation of CB1 receptors, Gi/o proteins, and ERK signaling. It was also indicated by this increased neural growth to entail antianxiety and antidepressant effects.

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HU-210, alongside other synthetic cannabinoids like WIN 55,212-2 and JWH-133, is implicated in preventing the inflammation caused by amyloid beta proteins involved in Alzheimer's disease, in addition to preventing cognitive impairment and loss of neuronal markers.

This anti-inflammatory action is induced through the activation of cannabinoid receptors, which prevents microglial activation that elicits the inflammation. In addition, cannabinoids completely abolish neurotoxicity related to microglia activation in rat models.

HU-210 is a potent analgesic with many of the same effects as natural THC.

HU-210 has an oral LD50 of 5,000mg/kg in rats and 14,200mg/kg in rabbits.[12] HU-210 has an LDLO (Lowest Lethal Dose amount) of 143mg/kg in humans. Caffeine has an LD50 estimated to be 150–200 milligrams per kilogram. Delta-8-THC LD50 has not been confirmed. In a 1973 study monkeys and dogs given 9,000mg/kg of Delta-8-THC was nonlethal

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HU-210 is a synthetic agonist analog of Δ9-THC, which is the primary psychoactive component of marijuana. HU-210 is a potent central cannabinoid (CB1)

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